凡畅,男,1997年10月,初级药师,2022年毕业于安徽中医药大学,获得硕士学位。研究方向为中医药防治肝纤维化。现主持安徽省高等学校科学研究项目1项,参与安徽省红十字会中医药传承创新发展项目1项,以第一作者发表学术论文4篇。
1. 教育经历
(1)2015.09—2019.06
安徽科技学院,生命与健康科学学院,中药学,本科,导师:刘汉珍
(2)2019.09—2022.06
安徽中医药大学,药学院,中药学,硕士,导师:姜辉
2. 工作经历
(1)2022.08—至今 安徽中医药大学第一附属医院
3. 主持科研项目情况
(1)安徽省教育厅, 安徽省高等学校科学研究项目, 2022AH050530, Prss8 m6A修饰调控TLR4炎症级联反应参与肝纤维化发病的机制及疏肝健脾方的干预研究, 2023-01至2024-12, 10万元, 在研, 主持
4.发表论文情况
(1)Fan C, Ma Y, Chen S, et al. Comprehensive Analysis of the Transcriptome-Wide m6A Methylation Modification Difference in Liver Fibrosis Mice by High-Throughput m6A Sequencing. Front Cell Dev Biol. 2021, 9:767051.
(2)Fan C, Wu FR, Zhang JF, Jiang H. A Network Pharmacology Approach to Explore the Mechanisms of Shugan Jianpi Formula in Liver Fibrosis. Evid Based Complement Alternat Med. 2020, 2020:4780383.
(3)Fan C, Cui X, Chen S, Huang S, Jiang H. LncRNA LOC100912373 modulates PDK1 expression by sponging miR-17-5p to promote the proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Am J Transl Res. 2020, 12(12):7709-7723.
(4)Jiang H, Fan C, Lu Y, Cui X, Liu J. Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis. Int J Mol Med. 2021, 48(1):130.
(5)Jiang H, Cao K, Fan C, Cui X, Ma Y, Liu J. Transcriptome-Wide High-Throughput m6A Sequencing of Differential m6A Methylation Patterns in the Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Cell Line MH7A. J Inflamm Res. 2021, 14:575-586.
(6)Jiang H, Liu J, Fan C, Wang J, Li W. lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast‑like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR‑152‑3p. Int J Mol Med. 2021, 47(3):17.
(7)凡畅; 吴芙蓉; 张家富; 姜辉 ; 细胞焦亡在肝纤维化发生发展中的作用, 临床肝胆病杂志, 2020, 36(05): 1138-1140 .
(8)陈森; 凡畅; 张家富; 马艳珍; 姜辉 ; 疏肝健脾方调控TLR4/MyD88/NLRP3信号轴抑制肝纤维化小鼠细胞焦亡的机制研究, 中国临床药理学与治疗学, 2022, 27(10): 1081-1089.
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